Flavopiridol hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3094
Cdk inhibitor; potently inhibits cdk2 and cdk9
Key Product Details
Description
Cdk inhibitor; potently inhibits cdk2 and cdk9
Alternative Names
L 86-8275
Product Description
Flavopiridol hydrochloride is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and <0.85 μM for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.Product Specifications
Molecular Weight
438.30
Formula
C21H20ClNO5.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
CAS Number
131740-09-5
PubChem ID
9910986
InChI Key
LGMSNQNWOCSPIK-LWHGMNCYSA-N
SMILES
CN(CC3)C[C@@H](O)[C@H]3[C@]1=C(OC(C4=CC=CC=C4Cl)=CC2=O)C2=C(O)C=C1O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 43.83 | 100 | |
| DMSO | 43.83 | 100 |
Preparing Stock Solutions
for Flavopiridol hydrochloride
The following data is based on the product molecular weight 438.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.41 mL | 22.82 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
- Ambrosini The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. Cancer Res. 2008 PMID: 18381438
- Losiewicz Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275. Biochem.Biophys.Res.Comm.
- Kaur Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275. J.Natl.Cancer.Inst. 1992 PMID: 1279187
Product Specific Notices for Flavopiridol hydrochloride
For research use only
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