Potent calcineurin inhibitor; immunosuppressant
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Key Product Details
Description: | Potent calcineurin inhibitor; immunosuppressant |
Alternative Names: | Tacrolimus, Fujimycin |
Chemical Name: | (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 804.02 |
Citations for FK 506 (39)
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Citations are publications that use Bio-Techne products. Selected citations for FK 506 include:
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Hugh P et al.
(2023)
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.
NPJ Parkinsons Dis.
9:4
PMID: 36646701 -
Armando A et al.
(2022)
Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes.
Cells.
11
PMID: 35203261 -
Kevin et al.
(2022)
Mild membrane depolarization in neurons induces immediate early gene transcription and acutely subdues responses to a successive stimulus.
J Biol Chem.
298:102278
PMID: 35863435 -
Zhongmei et al.
(2022)
RASA2 ablation in T cells boosts antigen sensitivity and long-term function.
Nature.
609:174-182
PMID: 36002574 -
Yan et al.
(2022)
LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function.
EMBO J.
41:e108119
PMID: 35099830 -
Jerzy W et al.
(2022)
Integrins Bidirectionally Regulate the Efficacy of Inhibitory Synaptic Transmission and Control GABAergic Plasticity.
J Neurosci.
42:5830-5842
PMID: 35701161 -
Satoe et al.
(2021)
Cell death-inducing cytotoxicity in truncated KCNQ4 variants associated with DFNA2 hearing loss.
Dis Model Mech.
14
PMID: 34622280 -
Paco S et al.
(2021)
Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity.
Cell Rep.
37:110142
PMID: 34936876 -
Timothy S et al.
(2021)
Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells.
J Immunol.
207:1275-1287
PMID: 34389624 -
Eleonora et al.
(2020)
Calcineurin Controls Expression of EAAT1/GLAST in Mouse and Human Cultured Astrocytes through Dynamic Regulation of Protein Synthesis and Degradation.
Int J Mol Sci.
21
PMID: 32210081 -
Douglas et al.
(2020)
Roles of glycogen synthase kinase 3 alpha and calcineurin in regulating the ability of sperm to fertilize eggs.
FASEB J.
34:1247-1269
PMID: 31914663 -
Mark L et al.
(2020)
Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation.
Cell Rep.
31:107785
PMID: 32579917 -
Christopher J et al.
(2020)
BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells.
Cell Rep.
31:107474
PMID: 32294437 -
Stuart N et al.
(2020)
TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses.
Nat Commun.
11:4614
PMID: 32929069 -
Chiu et al.
(2019)
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Cell Rep.
28:332
PMID: 31291571 -
Bradley J et al.
(2019)
Intracellular Ca2+ Homeostasis and Nuclear Export Mediate Exit from Naive Pluripotency.
Cell Stem Cell.
25:210-224.e6
PMID: 31104942 -
Torres et al.
(2018)
FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells.
Int J Mol Sci.
19
PMID: 30208561 -
Jing et al.
(2018)
Methods for High-throughput Drug Combination Screening and Synergy Scoring.
Methods Mol Biol.
1711:351-398
PMID: 29344898 -
Henson et al.
(2017)
Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning.
Neurobiol Learn Mem.
138:39
PMID: 27794462 -
Neustadtl et al.
(2017)
Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity.
Neuroreport.
28:618
PMID: 28542068 -
Stephen R et al.
(2017)
Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons.
J Neurosci.
37:8256-8272
PMID: 28751455 -
Jing et al.
(2017)
The Effects of Tacrolimus on T-Cell Proliferation Are Short-Lived: A Pilot Analysis of Immune Function Testing.
Transplant Direct.
3:e199
PMID: 28795150 -
Miyamoto et al.
(2016)
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
Cell Rep.
291:1719
PMID: 26589795 -
Matsa et al.
(2016)
Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro.
Cell Stem Cell..
19:311
PMID: 27545504 -
Palmqvist et al.
(2016)
A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030.
J Inflamm (Lond).
13:20
PMID: 27340371 -
Sharma et al.
(2016)
Protein Phosphatase 1-α Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle.
Diabetes.
65:2606
PMID: 27246912 -
Oh et al.
(2015)
Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons.
Iran J Basic Med Sci.
10:162
PMID: 25558061 -
Hadjiasgary et al.
(2015)
Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm.
J Neurosci.
18:130
PMID: 25810886 -
Codeluppi et al.
(2014)
Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling.
PLoS One.
9:e92649
PMID: 24667246 -
Chiodi et al.
(2014)
Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.
Neuropsychopharmacology.
39:569
PMID: 23989619 -
Mirante et al.
(2014)
Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
J Biol Chem.
7:62
PMID: 25071439 -
Sharanek et al.
(2014)
Different dose-dependent mechanisms are involved in early cyclosp. a-induced cholestatic effects in hepaRG cells.
Toxicol Sci.
141:244
PMID: 24973091 -
Lars et al.
(2014)
Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.
J Clin Invest.
124:3793-806
PMID: 25083990 -
Cai et al.
(2013)
Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain.
J Pharmacol Exp Ther.
345:161
PMID: 23386250 -
Vliet et al.
(2013)
Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
J Biol Chem.
288:27519
PMID: 23918927 -
Pont et al.
(2012)
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
Mol.Endocrinol..
26:1743
PMID: 22902539 -
Marra et al.
(2012)
A preferentially segregated recycling vesicle pool of limited size supports neurotransmission in native central synapses.
Neuron.
76:579
PMID: 23141069 -
Lin et al.
(2011)
AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.
Br J Pharmacol.
31:1323
PMID: 21273417 -
Zhen et al.
(2009)
Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex.
J Neurosci.
29:550-62
PMID: 19144855
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Customer Reviews for FK 506 (2)
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Species: RatAssay Type: In VitroCell Line/Tissue: Sprague-Dawley rats primary neuronalFK506 for PP2B (FK, 1 μM)
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Species: HumanFK 506 was tested for its antibiotic properties. FK 506, a treatment for primary sclerosing cholangitis: results of an open-label preliminary trial.
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