FIIN 1 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4002
Potent, irreversible FGFR inhibitor
Discontinued Product
4002 has been discontinued.
View all FGF Receptor Inhibitors products.
Key Product Details
Description
Potent, irreversible FGFR inhibitor
Product Description
FIIN 1 hydrochloride is a potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).Product Specifications
Molecular Weight
693.06
Formula
C32H39Cl2N7O4
Storage
Store at -20°C
Purity
≥96% (HPLC)
Chemical Name
N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide
CAS Number
1256152-35-8
PubChem ID
90488902
InChI Key
IQLGDXNKTDKSMY-UHFFFAOYSA-N
SMILES
CCN(CC)CCCCNC1=NC=C2C(N(CC3=CC=CC(NC(C=C)=O)=C3)C(N(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C2)=O)=N1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 69.31 | 100 | |
| Ethanol | 69.31 | 100 |
Preparing Stock Solutions
for FIIN 1 hydrochloride
The following data is based on the product molecular weight 693.06
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.44 mL | 7.21 mL | 14.43 mL |
| 5 mM | 0.29 mL | 1.44 mL | 2.89 mL |
| 10 mM | 0.14 mL | 0.72 mL | 1.44 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.29 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhou A structure-guided approach to creating covalent FGFR inhibitors. Chem.Biol. 2010 PMID: 20338520
Product Specific Notices for FIIN 1 hydrochloride
For research use only
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