FIIN 1 hydrochloride

Name: FIIN 1 hydrochloride
Brand: Tocris Bioscience
SKU: 4002

Tocris Bioscience a Bio-Techne Brand

Catalog # 4002

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Key Product Details

Description:	Potent, irreversible FGFR inhibitor
Chemical Name:	N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide
Purity:	≥96% (HPLC)
Molecular Weight:	693.06

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Biological Activity for FIIN 1 hydrochloride

FIIN 1 hydrochloride is a potent, irreversible FGFR inhibitor (K_d values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (K_d values are 32, 120 and 210 nM respectively); displays limited activity (K_d >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC₅₀ values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).

Technical Data for FIIN 1 hydrochloride

M. Wt	693.06
Formula	C₃₂H₃₉Cl₂N₇O₄
Storage	Store at -20°C
Purity	≥96% (HPLC)
CAS Number	1256152-35-8
PubChem ID	90488902
InChi Key	IQLGDXNKTDKSMY-UHFFFAOYSA-N
Smiles	CCN(CC)CCCCNC1=NC=C2C(N(CC3=CC=CC(NC(C=C)=O)=C3)C(N(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C2)=O)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FIIN 1 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	69.31	100
	ethanol	69.31	100

Preparing Stock Solutions for FIIN 1 hydrochloride

The following data is based on the product molecular weight 693.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.44 mL	7.21 mL	14.43 mL
5 mM	0.29 mL	1.44 mL	2.89 mL
10 mM	0.14 mL	0.72 mL	1.44 mL
50 mM	0.03 mL	0.14 mL	0.29 mL

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References for FIIN 1 hydrochloride

References are publications that support the biological activity of the product.

Zhou A structure-guided approach to creating covalent FGFR inhibitors. Chem.Biol. 2010 PMID: 20338520

Citations for FIIN 1 hydrochloride

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FIIN 1 hydrochloride

Tocris Bioscience a Bio-Techne Brand

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Biological Activity for FIIN 1 hydrochloride

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Preparing Stock Solutions for FIIN 1 hydrochloride

Molarity Calculator

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Reconstitution Calculator

References for FIIN 1 hydrochloride

Citations for FIIN 1 hydrochloride

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