FICZ

Tocris Bioscience a Bio-Techne Brand

Catalog # 5304

Citations (1)

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Key Product Details

Description:	High affinity aryl hydrocarbon receptor (AhR) agonist
Chemical Name:	5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
Purity:	≥95% (HPLC)
Molecular Weight:	284.31

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Biological Activity for FICZ

FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (K_d = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.

Technical Data for FICZ

M. Wt	284.31
Formula	C₁₉H₁₂N₂O
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	172922-91-7
PubChem ID	1863
InChi Key	ZUDXFBWDXVNRKF-UHFFFAOYSA-N
Smiles	[H]C(C1=C2C(C(C=CC=C3)=C3N2)=CC4=C1C(C=CC=C5)=C5N4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FICZ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.11	25

Preparing Stock Solutions for FICZ

The following data is based on the product molecular weight 284.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	14.07 mL	70.35 mL	140.69 mL
1.25 mM	2.81 mL	14.07 mL	28.14 mL
2.5 mM	1.41 mL	7.03 mL	14.07 mL
12.5 mM	0.28 mL	1.41 mL	2.81 mL

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References for FICZ

References are publications that support the biological activity of the product.

Moura-Alves AhR sensing of bacterial pigments regulates antibacterial defence. Nature 2014 PMID: 25119038
Wincent The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 2009 PMID: 19054769
Rannug Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 1995 PMID: 8807817

Citations for FICZ (1)

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Citations are publications that use Bio-Techne products. Selected citations for FICZ include:

Tagliabue et al. (2019) Modeling the binding of diverse ligands within the Ah receptor ligand binding domain. Sci Rep. 9:10693
PMID: 31337850

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Product Documents for FICZ

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.