FICZ
Tocris Bioscience, part of Bio-Techne | Catalog # 5304
High affinity aryl hydrocarbon receptor (AhR) agonist
Key Product Details
Description
High affinity aryl hydrocarbon receptor (AhR) agonist
Product Description
FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro.Product Specifications
Molecular Weight
284.31
Formula
C19H12N2O
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
CAS Number
172922-91-7
PubChem ID
1863
InChI Key
ZUDXFBWDXVNRKF-UHFFFAOYSA-N
SMILES
[H]C(C1=C2C(C(C=CC=C3)=C3N2)=CC4=C1C(C=CC=C5)=C5N4)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.11 | 25 |
Preparing Stock Solutions
for FICZ
The following data is based on the product molecular weight 284.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 14.07 mL | 70.35 mL | 140.69 mL |
| 1.25 mM | 2.81 mL | 14.07 mL | 28.14 mL |
| 2.5 mM | 1.41 mL | 7.03 mL | 14.07 mL |
| 12.5 mM | 0.28 mL | 1.41 mL | 2.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wincent The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 2009 PMID: 19054769
- Moura-Alves AhR sensing of bacterial pigments regulates antibacterial defence. Nature 2014 PMID: 25119038
- Rannug Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 1995 PMID: 8807817
Product Specific Notices for FICZ
For research use only
Loading...
Loading...