FHT 2344

Name: FHT 2344
Brand: Tocris Bioscience
SKU: 7645

Tocris Bioscience, part of Bio-Techne | Catalog # 7645

COA / SDS

Potent SMARCA2/4 inhibitor

Key Product Details

Description:	Potent SMARCA2/4 inhibitor
Chemical Name:	N-[(1S)-1-(Methoxymethyl)-2-[[4-[3-(1-methyl-1H-pyrazol-3-yl)phenyl]-2-thiazolyl]amino]-2-oxoethyl]-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	528.6

View Full Technical Details for FHT 2344

Technical Data
Citations

Biological Activity for FHT 2344

FHT 2344 is a potent allosteric and ATP-competitive inhibitor of SMARCA2/SMARCA4 ATPases (also known as BRM/BRG1) of the BAF complex (IC₅₀ values are 13.8 and 26.1 nM at SMARCA2 and SMARCA4, respectively). FHT 2344 inhibits SMARCA2 transcriptional activity in a BRG1-mutant cell line and SMARCA4 transcription in a BRM-mutant cell line (IC₅₀ values are 29.8 and 30.2 nM, respectively). Dose-dependently reduces tumor growth in a uveal melanoma xenograft model and suppresses SOX10 transcription.

Licensing Information

Sold under license from Foghorn Therapeutics

Technical Data for FHT 2344

M. Wt	528.6
Formula	C₂₃H₂₄N₆O₅S₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2468058-90-2
InChi Key	APLVGTKXOIMODQ-IBGZPJMESA-N
Smiles	COC[C@@H](C(NC1=NC(C2=CC(C3=NN(C=C3)C)=CC=C2)=CS1)=O)NC(C4=CN(S(C)(=O)=O)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FHT 2344

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.43	50

Preparing Stock Solutions for FHT 2344

The following data is based on the product molecular weight 528.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.78 mL	18.92 mL	37.84 mL
2.5 mM	0.76 mL	3.78 mL	7.57 mL
5 mM	0.38 mL	1.89 mL	3.78 mL
25 mM	0.08 mL	0.38 mL	0.76 mL

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References for FHT 2344

References are publications that support the biological activity of the product.

Centore Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers. Cancer Res.