FHT 1015
Tocris Bioscience, part of Bio-Techne | Catalog # 7644
Potent and selective SMARCA4/2 inhibitor
Key Product Details
Description
Potent and selective SMARCA4/2 inhibitor
Product Description
FHT 1015 is a potent and selective allosteric inhibitor of SMARCA4/SMARCA2 ATPase (also known as BRG1/BRM respectively) of the BAF (BRG/Brahma-associated factors) complex, with IC50s of ≤ 10 nM. Exhibits selectivity for SMARCA4/SMARCA2 over related CHD4 (IC50 of > 400 μM). Mutations in I1143 on SMARCA4 and I1173 on SMARCA2 render these proteins resistant to inhibition by FHT 1015. The compound induces lineage-specific changes in chromatin accessibility in different cancer cell lines, preventing binding of cancer-associated transcription factors, SOX10 and MITF transcription factors.Licensing Information
Sold under license from Foghorn Therapeutics Inc.Product Specifications
Molecular Weight
555.69
Formula
C25H25N5O4S3
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(S)-1-(Methylsulfonyl)-N-[4-(methylthio)-1-oxo-1-[[4-[3-(pyridin-4-yl)phenyl]thiazol-2-yl]amino]butan-2-yl]-1H-pyrrole-3-carboxamide
CAS Number
2368903-18-6
PubChem ID
139371523
InChI Key
FAYSHZVDWADZMD-NRFANRHFSA-N
SMILES
CSCC[C@@H](C(NC1=NC(C2=CC(C3=CC=NC=C3)=CC=C2)=CS1)=O)NC(C4=CN(S(C)(=O)=O)C=C4)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.57 | 100 |
Preparing Stock Solutions
for FHT 1015
The following data is based on the product molecular weight 555.69
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.80 mL | 9.00 mL | 18.00 mL |
| 5 mM | 0.36 mL | 1.80 mL | 3.60 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.80 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Centore Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers. Cancer Res.
Product Specific Notices for FHT 1015
For research use only
Loading...
Loading...