FG 7142

Name: FG 7142
Brand: Tocris Bioscience
SKU: 0554
Price: 212 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0554

Citations (4)

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Key Product Details

Description:	Benzodiazepine inverse agonist
Chemical Name:	N-Methyl-β-carboline-3-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	225.25

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Biological Activity for FG 7142

FG 7142 is a benzodiazepine inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.

Compound Libraries for FG 7142

FG 7142 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for FG 7142

M. Wt	225.25
Formula	C₁₃H₁₁N₃O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	78538-74-6
PubChem ID	4375
InChi Key	QMCOPDWHWYSJSA-UHFFFAOYSA-N
Smiles	CNC(=O)C1=CC2=C(NC3=C2C=CC=C3)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FG 7142

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	16.89	75
	DMSO	22.52	100

Preparing Stock Solutions for FG 7142

The following data is based on the product molecular weight 225.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.44 mL	22.20 mL	44.40 mL
5 mM	0.89 mL	4.44 mL	8.88 mL
10 mM	0.44 mL	2.22 mL	4.44 mL
50 mM	0.09 mL	0.44 mL	0.89 mL

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References for FG 7142

References are publications that support the biological activity of the product.

Donner Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents. Naunyn Schmiedebergs Arch.Pharmacol. 1989 PMID: 2478895
Knorr The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 1989 PMID: 2765936
Wettstei Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys. Eur.J.Pharmacol. 1989 PMID: 2498110
Stanford A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors. Eur.J.Pharmacol. 1987 PMID: 3032657

Citations for FG 7142 (4)

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Citations are publications that use Bio-Techne products. Selected citations for FG 7142 include:

Lukkes et al. (2012) Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats. Physiol Behav. 107:719
PMID: 22583860
Lukkes et al. (2012) Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems. Brain Res. 1443:1
PMID: 22297173
Johnson et al. (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Life Sci. 107:733
PMID: 22554617
Major et al. (2009) The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta). J Neurosci. 85:753
PMID: 19837095

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