Fexaramine

Tocris Bioscience, part of Bio-Techne | Catalog # 2563

Potent, selective farnesoid X receptor (FXR) agonist
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Key Product Details

Description

Potent, selective farnesoid X receptor (FXR) agonist

View all LXR-like Receptor Agonists »

Product Description

Fexaramine is a potent, selective farnesoid X receptor agonist (EC50 = 25 nM). Displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.

Product Specifications

Molecular Weight

496.64

Formula

C32H36N2O3

Storage

Desiccate at +4°C

Purity

≥97% (HPLC)

Chemical Name

3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid methyl ester

CAS Number

574013-66-4

PubChem ID

5326713

InChI Key

VLQTUNDJHLEFEQ-KGENOOAVSA-N

SMILES

O=C(C3CCCCC3)N(CC2=CC=C(C4=CC=C(N(C)C)C=C4)C=C2)C1=CC(/C=C/C(OC)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.66 100

Preparing Stock Solutions for Fexaramine

The following data is based on the product molecular weight 496.64

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.14 mL
5 mM 0.40 mL 2.01 mL 4.03 mL
10 mM 0.20 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Fexaramine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Fexaramine

For research use only

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