Fatostatin A
Tocris Bioscience, part of Bio-Techne | Catalog # 4444
Cell permeable inhibitor of SREBP activation
Key Product Details
Description
Cell permeable inhibitor of SREBP activation
Product Description
Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC50 = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.Product Specifications
Molecular Weight
375.33
Formula
C18H18N2S.HBr
Storage
Store at +4°C
Purity
≥97% (HPLC)
Chemical Name
4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide
CAS Number
298197-04-3
PubChem ID
2850562
InChI Key
RJCFNQZVFUMORB-UHFFFAOYSA-N
SMILES
CCCC1=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=CC=N1.Br
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.51 | 20 |
Preparing Stock Solutions
for Fatostatin A
The following data is based on the product molecular weight 375.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.32 mL | 66.61 mL | 133.22 mL |
| 1 mM | 2.66 mL | 13.32 mL | 26.64 mL |
| 2 mM | 1.33 mL | 6.66 mL | 13.32 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Choi Identification of bioactive molecules by adipogenesis profiling of organic compounds. J.Biol.Chem. 2003 PMID: 12496288
- Kamisuki A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem.Biol. 2009 PMID: 19716478
Product Specific Notices for Fatostatin A
For research use only
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