EXP 3174
Tocris Bioscience, part of Bio-Techne | Catalog # 5728
Potent and selective AT1 antagonist
Key Product Details
Description
Potent and selective AT1 antagonist
Product Description
EXP 3174 is a potent and selective noncompetitive AT1 receptor antagonist (IC50 = 37 nM). Reduces blood pressure in a rat model. Active metabolite of Losartan potassium (Cat. No. 3798).Product Specifications
Molecular Weight
436.89
Formula
C22H21ClN6O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
CAS Number
124750-92-1
PubChem ID
108185
InChI Key
ZEUXAIYYDDCIRX-UHFFFAOYSA-N
SMILES
CCCCC1=NC(Cl)=C(C(O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.69 | 100 | |
| Ethanol | 43.69 | 100 |
Preparing Stock Solutions
for EXP 3174
The following data is based on the product molecular weight 436.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.44 mL | 22.89 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wong Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 1990 PMID: 2213556
Product Specific Notices for EXP 3174
For research use only
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