Eticlopride hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1847
D2 and D3 antagonist (D3 > D2)
Key Product Details
Description
D2 and D3 antagonist (D3 > D2)
Alternative Names
(-)-Eticlopride
Product Description
Eticlopride hydrochloride is a selective dopamine D2/D3 receptor antagonist (Ki values are 0.50 and 0.16 nM respectively). Antipsychotic.Product Specifications
Molecular Weight
377.31
Formula
C17H25ClN2O3.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamide hydrochloride
CAS Number
97612-24-3
PubChem ID
57266
InChI Key
HFJFXXDHVWLIKX-YDALLXLXSA-N
SMILES
O=C(C2=C(OC)C(Cl)=CC(CC)=C2O)NC[C@@H]1CCCN1CC.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 37.73 | 100 |
Preparing Stock Solutions
for Eticlopride hydrochloride
The following data is based on the product molecular weight 377.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.25 mL | 26.50 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.30 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Giuliani and Ferrari Involvement of DA receptors in the antipsychotic profile of (-) eticlopride. Physiol.Behav. 1997 PMID: 9108576
- Claytor The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys. Pharmacol.Biochem.Behav. 2006 PMID: 16631246
- Hall Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for DA-D2 receptors in the rat brain. Eur.J.Pharmacol. 1985 PMID: 4018125
Product Specific Notices for Eticlopride hydrochloride
For research use only
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