ER 50891
Tocris Bioscience, part of Bio-Techne | Catalog # 3823
Selective RARα antagonist
Key Product Details
Description
Selective RARα antagonist
Product Description
ER 50891 is an antagonist of RARα receptors (IC50 = 31.2 nM). Displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively).Product Specifications
Molecular Weight
432.51
Formula
C29H24N2O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-[5-[8-(1-Methylethyl)-4-phenyl-2-quinolinyl]-1H-pyrrolo-2-benzoic acid
CAS Number
187400-85-7
PubChem ID
10094345
InChI Key
LSGNKLDHMQVTEK-UHFFFAOYSA-N
SMILES
CC(C)C1=C2C(C(C3=CC=CC=C3)=CC(C4=CC=C(C5=CC=C(C(O)=O)C=C5)N4)=N2)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.25 | 100 |
Preparing Stock Solutions
for ER 50891
The following data is based on the product molecular weight 432.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.31 mL | 11.56 mL | 23.12 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.62 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.31 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ren Impaired retinoic acid (RA) signal leads to RARβ2 epigenetic silencing and RA resistance. Mol.Cell.Biol. 2005 PMID: 16287870
- Somenzi Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. PLoS ONE 2007 PMID: 17786207
- Kikuchi Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists. Bioorg.Med.Chem.Lett. 2001 PMID: 11354380
Product Specific Notices for ER 50891
For research use only
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