ER 27319 maleate
Tocris Bioscience, part of Bio-Techne | Catalog # 2471
Selective Syk kinase inhibitor
Product Description
ER 27319 maleate is a selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events.Product Specifications
Molecular Weight
396.17
Formula
C18H20N2O.C4H4O4
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate
CAS Number
1204480-26-1
PubChem ID
56972172
InChI Key
WVUQPGFRFBVJKH-BTJKTKAUSA-N
SMILES
OC(=O)\C=C/C(O)=O.CC1=C(C)C2=C(C=C1)C(=O)C1=CC=CC=C1N2CCCN
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.71 | 75 | |
| DMSO | 39.62 | 100 |
Preparing Stock Solutions
for ER 27319 maleate
The following data is based on the product molecular weight 396.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.62 mL | 25.24 mL |
| 5 mM | 0.50 mL | 2.52 mL | 5.05 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Moriya ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk. Proc.Natl.Acad.Sci.USA
- Luskova and Draber Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr.Pharm.Des. 2004 PMID: 15180535
Product Specific Notices for ER 27319 maleate
For research use only
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