Eplivanserin hemifumarate

Tocris Bioscience, part of Bio-Techne | Catalog # 4958

Potent and selective 5-HT2A antagonist
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Key Product Details

Description

Potent and selective 5-HT2A antagonist

Alternative Names

SR-46349 hemifumarate,SR-46349B

View all 5-HT2A Receptor Antagonists »

Product Description

Eplivanserin hemifumarate is a potent and selective 5-HT2A antagonist (IC50 values are 5.8 and 120 and >100 nM for 5-HT2A, 5-HT2B and 5-HT2C, respectively). Attenuates cocaine-induced hyperactivity. Increases dopamine (DA) release in rat medial prefrontal cortex (mPFC); potentiates haloperidol-induced DA release in the mPFC and nucleus accumbens.

Product Specifications

Molecular Weight

386.42

Formula

C19H21FN2O2.0.5C4H4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(1Z,2E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime hemifumarate

CAS Number

130580-02-8

PubChem ID

6438382

InChI Key

UCLIFEBROADCQW-PWERMGERSA-N

SMILES

OC(C=C2)=CC=C2/C=C/C(C1=CC=CC=C1F)=N/OCCN(C)C.O=C(/C=C/C(O)=O)O.OC(C=C4)=CC=C4/C=C/C(C3=CC=CC=C3F)=N/OCCN(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.32 50

Preparing Stock Solutions for Eplivanserin hemifumarate

The following data is based on the product molecular weight 386.42

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.18 mL 25.88 mL 51.76 mL
2.5 mM 1.04 mL 5.18 mL 10.35 mL
5 mM 0.52 mL 2.59 mL 5.18 mL
25 mM 0.10 mL 0.52 mL 1.04 mL

Calculators

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Product Documents for Eplivanserin hemifumarate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Eplivanserin hemifumarate

For research use only

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