EO 1428
Tocris Bioscience, part of Bio-Techne | Catalog # 2908
Selective inhibitor of p38α and p38β2
Product Description
EO 1428 is a selective inhibitor of p38α and p38β2 that displays no activity at p38γ, p38δ, ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC50 values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis.Product Specifications
Molecular Weight
415.71
Formula
C20H16BrClN2O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone
CAS Number
321351-00-2
PubChem ID
9801969
InChI Key
HDCLCHNAEZNGNV-UHFFFAOYSA-N
SMILES
CC1=CC=CC=C1C(C2=CC=C(NC3=C(N)C=C(Br)C=C3)C=C2Cl)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.57 | 100 | |
| Ethanol | 20.79 | 50 |
Preparing Stock Solutions
for EO 1428
The following data is based on the product molecular weight 415.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.03 mL | 24.06 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.81 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ottosen Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J.Med.Chem. 2003 PMID: 14667219
Product Specific Notices for EO 1428
For research use only
Loading...
Loading...