EM 12-FS
Tocris Bioscience, part of Bio-Techne | Catalog # 7851
Molecular glue; induces degradation of NQAT1
Key Product Details
Description
Molecular glue; induces degradation of NQAT1
Alternative Names
Selective NTAQ1 degrader
Product Description
EM12-FS is a selective N-terminal glutamine amidohydrolase 1 (NTAQ1) Degrader. In MOLT4 cells, it downregulates NTAQ1 via cereblon-mediated degradation (IC50 = 256 nM). Requires covalent His353 engagement to recruit and degrade NTAQ1.Product Specifications
Molecular Weight
342.30
Formula
C13H11FN2O6S
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
3-[6-[(Fluorosulfonyl)oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
CAS Number
2839138-44-0
PubChem ID
165879822
InChI Key
RXYXBYLQECASPH-UHFFFAOYSA-N
SMILES
O=C1NC(C(CC1)N2C(C3=CC(OS(=O)(F)=O)=CC=C3C2)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.23 | 100 |
Preparing Stock Solutions
for EM 12-FS
The following data is based on the product molecular weight 342.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.61 mL | 29.21 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cruite Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem.Biol. 2022 PMID: 36128501
Product Specific Notices for EM 12-FS
For research use only
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