eIF4A i28
Tocris Bioscience, part of Bio-Techne | Catalog # 7810
eIF4A inhibitor
Key Product Details
Description
eIF4A inhibitor
Product Description
eIF4A i28 is a eukaryotic initiation factor-4A (eIF4A) inhibitor (IC50 = 8.60 μM in an eIF4A ATPase assay). It decreases BJAB Burkitt lymphoma cell viability (EC50 = 0.46 μM in a CellTiter-Glo (CTG) luminescence cell viability assay. It acts as an RNA-competitive, ATP-uncompetitive eIF4A inhibitor.Licensing Information
Sold under license from the University of ArizonaProduct Specifications
Molecular Weight
416.43
Formula
C24H20N2O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(5-(4-Butylphenyl)furan-2-yl)-6-nitroquinoline-4-carboxylic acid
CAS Number
2861994-92-3
PubChem ID
163198549
InChI Key
UDCAKLDMNJRQKW-UHFFFAOYSA-N
SMILES
CCCCC1=CC=C(C2=CC=C(C3=NC4=CC=C(C=C4C(C(O)=O)=C3)[N+]([O-])=O)O2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.33 | 20 |
Preparing Stock Solutions
for eIF4A i28
The following data is based on the product molecular weight 416.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.01 mL | 60.03 mL | 120.07 mL |
| 1 mM | 2.40 mL | 12.01 mL | 24.01 mL |
| 2 mM | 1.20 mL | 6.00 mL | 12.01 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zerio Discovery of an eIF4A inhibitor with a novel mechanism of action. J.Med.Chem. 2021 PMID: 34676755
Product Specific Notices for eIF4A i28
For research use only
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