Edaravone

Name: Edaravone
Brand: Tocris Bioscience
SKU: 0786

Tocris Bioscience, part of Bio-Techne | Catalog # 0786

Citations (1)

COA / SDS

Anti-ischemic and antioxidant

Discontinued Product

0786 has been discontinued. View all Additional Antioxidant Compounds products.

Key Product Details

Description:	Anti-ischemic and antioxidant
Alternative Names:	MCI-186
Chemical Name:	3-Methyl-1-phenyl-2-pyrazolin-5-one
Purity:	≥99% (HPLC)
Molecular Weight:	174.2

View Full Technical Details for Edaravone

Technical Data
Citations

Biological Activity for Edaravone

Edaravone is a radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.

Technical Data for Edaravone

M. Wt	174.2
Formula	C₁₀H₁₀N₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	89-25-8
PubChem ID	4021
InChi Key	QELUYTUMUWHWMC-UHFFFAOYSA-N
Smiles	CC1=NN(C(=O)C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Edaravone

References are publications that support the biological activity of the product.

Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
Kawasaki Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J.Pharmacol.Exp.Ther. 2007 PMID: 17429058
Watanabe Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J.Pharmacol.Exp.Ther. 1994 PMID: 8138971
Kawai Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model. J.Pharmacol.Exp.Ther. 1997 PMID: 9152402

Edaravone

Tocris Bioscience, part of Bio-Techne | Catalog # 0786

Key Product Details

Biological Activity for Edaravone

Technical Data for Edaravone

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Edaravone

Product Documents for Edaravone

COA

Certificate of Analysis

SDS

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