Edaravone

Name: Edaravone
Brand: tocris
SKU: 0786

Catalog # 0786

Citations (3)

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	Anti-ischemic and antioxidant
Alternative Names:	MCI-186
Chemical Name:	3-Methyl-1-phenyl-2-pyrazolin-5-one
Purity:	≥99% (HPLC)
Molecular Weight:	174.2

View Full Technical Details for Edaravone

Biological Activity

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.

Technical Data

M. Wt	174.2
Formula	C₁₀H₁₀N₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	89-25-8
PubChem ID	4021
InChi Key	QELUYTUMUWHWMC-UHFFFAOYSA-N
Smiles	CC1=NN(C(=O)C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.42	100

Preparing Stock Solutions

The following data is based on the product molecular weight 174.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.74 mL	28.70 mL	57.41 mL
5 mM	1.15 mL	5.74 mL	11.48 mL
10 mM	0.57 mL	2.87 mL	5.74 mL
50 mM	0.11 mL	0.57 mL	1.15 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Kawai Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model. J.Pharmacol.Exp.Ther. 1997 PMID: 9152402
Kawasaki Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J.Pharmacol.Exp.Ther. 2007 PMID: 17429058
Watanabe Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J.Pharmacol.Exp.Ther. 1994 PMID: 8138971
Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316

Citations (3)

Showing 1 - 3 of 3 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Edaravone include:

Wu et al. (2019) Phorbol ester-induced angiogenesis of endothelial progenitor cells: The role of NADPH oxidase-mediated, redox-related matrix metalloproteinase pathways. PLoS One. 14:e0209426
PMID: 30645596
Tsunekawa et al. (2013) Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation. Br J Pharmacol. 14:4
PMID: 23289926
Walton et al. (2012) Adult neurogenesis transiently generates oxidative stress. PLoS One. 7:e35264
PMID: 22558133

There are no citations that match your criteria.

Showing 1 - 3 of 3 citations Showing All

Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

Edaravone

Order Information

Shipping Information

Key Product Details

Complete Your Research

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (3)

Product Datasheets

COA

Certificate of Analysis

SDS

Bio-Techne Brands

Stay Connected