Edaglitazone
Tocris Bioscience, part of Bio-Techne | Catalog # 4784
Potent and selective PPARγ agonist; antidiabetic
Key Product Details
Description
Potent and selective PPARγ agonist; antidiabetic
Alternative Names
R 483,BM 131258
Product Description
Edaglitazone is a potent and selective PPARγ agonist (EC50 values are 35.6 and 1053 nM for PPARγ and PPARα cofactor recruitment respectively. Enhances insulin sensitivity in obese, but not lean, rats. Antidiabetic and orally bioavailable.Product Specifications
Molecular Weight
464.56
Formula
C24H20N2O4S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-[[4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-2,4-thiazolidinedione
CAS Number
213411-83-7
PubChem ID
9825701
InChI Key
HAAXAFNSRADSMK-UHFFFAOYSA-N
SMILES
CC(OC(C5=CC=CC=C5)=N4)=C4CCOC(C3=C2SC=C3)=CC=C2CC1C(NC(S1)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 |
Preparing Stock Solutions
for Edaglitazone
The following data is based on the product molecular weight 464.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.76 mL | 21.53 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.31 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dietz Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem 2012 PMID: 22489042
- Fürnsinn Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism. Br. J. Pharmacol. 1999 PMID: 10578125
Product Specific Notices for Edaglitazone
For research use only
Loading...
Loading...