E 2012
Tocris Bioscience, part of Bio-Techne | Catalog # 5550
γ-secretase modulator; Notch-sparing
Key Product Details
Description
γ-secretase modulator; Notch-sparing
Product Description
E 2012 is a γ-secretase modulator. Lowers Aβ40 and Aβ42 levels and increases Aβ37 levels, in vitro and in vivo. Displays no effect on γ-secretase processing of Notch, EphA4 and EphB2.Product Specifications
Molecular Weight
419.49
Formula
C25H26FN3O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3E)-1-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-2-piperidone
CAS Number
870843-42-8
PubChem ID
11560787
InChI Key
PUOAETJYKQITMO-LANLRWRYSA-N
SMILES
COC1=C(N2C=C(C)N=C2)C=CC(/C=C3CCCN([C@@H](C)C4=CC=C(F)C=C4)C\3=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 41.95 | 100 | |
| DMSO | 41.95 | 100 |
Preparing Stock Solutions
for E 2012
The following data is based on the product molecular weight 419.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.92 mL | 23.84 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Portelius Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs. J.Alzheimers Dis. 2010 PMID: 20634579
- Borgegard First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. J.Biol.Chem. 2012 PMID: 22334705
Product Specific Notices for E 2012
For research use only
Loading...
Loading...