Dynarrestin
Tocris Bioscience, part of Bio-Techne | Catalog # 6526
Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
Key Product Details
Description
Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
Product Description
Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.Product Specifications
Molecular Weight
431.50
Formula
C22H23F2N3O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate
CAS Number
2222768-84-3
PubChem ID
137919864
InChI Key
UZNNDDDSGCMQOQ-UHFFFAOYSA-N
SMILES
CCOC(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(S1)NC3=C(C=C(C=C3)F)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.15 | 100 |
Preparing Stock Solutions
for Dynarrestin
The following data is based on the product molecular weight 431.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.59 mL | 23.17 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Höing Dynarrestin, a novel inhibitor or cytoplasmic dynein. Cell Chem.Biol. 2018 PMID: 29396292
Product Specific Notices for Dynarrestin
For research use only
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