Dynapyrazole A

Name: Dynapyrazole A
Brand: Tocris Bioscience
SKU: 6896

Tocris Bioscience, part of Bio-Techne | Catalog # 6896

Citations (1)

COA / SDS

Hedgehog signaling inhibitor; dynein inhibitor

Key Product Details

Description:	Hedgehog signaling inhibitor; dynein inhibitor
Chemical Name:	2-[1-(4-Chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxopyrazolo[1,5-a]quinazoline-3-carbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	486.7

View Full Technical Details for Dynapyrazole A

Technical Data
Citations

Biological Activity for Dynapyrazole A

Dynapyrazole A is a dynein inhibitor. Inhibits dynein 1 and dynein 2-dependent microtubule gliding (IC₅₀ values are 2.3 and 2.6 μM, respectively). Inhibits hedgehog signaling in vitro (IC₅₀ = 1.9 μM). Displays reversible inhibition of retrograde and anterograde intraflagellar transport in Chlamydomonas; displays stronger inhibition of retrograde transport.

Compound Libraries for Dynapyrazole A

Dynapyrazole A is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Dynapyrazole A

M. Wt	486.7
Formula	C₂₀H₁₂ClIN₄O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2226517-75-3
PubChem ID	136213044
InChi Key	VABPBCMFKJDOHP-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C2(C3=NN4C(NC(C5=CC(I)=CC=C45)=O)=C3C#N)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dynapyrazole A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.73	20

Preparing Stock Solutions for Dynapyrazole A

The following data is based on the product molecular weight 486.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.27 mL	51.37 mL	102.73 mL
1 mM	2.05 mL	10.27 mL	20.55 mL
2 mM	1.03 mL	5.14 mL	10.27 mL
10 mM	0.21 mL	1.03 mL	2.05 mL

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References for Dynapyrazole A

References are publications that support the biological activity of the product.

Steinman Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. Elife 2017 PMID: 28524820