Dynapyrazole A
Tocris Bioscience, part of Bio-Techne | Catalog # 6896
Hedgehog signaling inhibitor; dynein inhibitor
Key Product Details
Description
Hedgehog signaling inhibitor; dynein inhibitor
Product Description
Dynapyrazole A is a dynein inhibitor. Inhibits dynein 1 and dynein 2-dependent microtubule gliding (IC50 values are 2.3 and 2.6 μM, respectively). Inhibits hedgehog signaling in vitro (IC50 = 1.9 μM). Displays reversible inhibition of retrograde and anterograde intraflagellar transport in Chlamydomonas; displays stronger inhibition of retrograde transport.Product Specifications
Molecular Weight
486.70
Formula
C20H12ClIN4O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[1-(4-Chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxopyrazolo[1,5-a]quinazoline-3-carbonitrile
CAS Number
2226517-75-3
PubChem ID
136213044
InChI Key
VABPBCMFKJDOHP-UHFFFAOYSA-N
SMILES
ClC1=CC=C(C2(C3=NN4C(NC(C5=CC(I)=CC=C45)=O)=C3C#N)CC2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.73 | 20 |
Preparing Stock Solutions
for Dynapyrazole A
The following data is based on the product molecular weight 486.70
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.27 mL | 51.37 mL | 102.73 mL |
| 1 mM | 2.05 mL | 10.27 mL | 20.55 mL |
| 2 mM | 1.03 mL | 5.14 mL | 10.27 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Steinman Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. Elife 2017 PMID: 28524820
Product Specific Notices for Dynapyrazole A
For research use only
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