DY 268

Name: DY 268
Brand: Tocris Bioscience
SKU: 5656

Tocris Bioscience, part of Bio-Techne | Catalog # 5656

Citations (8)

COA / SDS

Potent FXR antagonist

Key Product Details

Description:	Potent FXR antagonist
Chemical Name:	1-[(3-Methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	560.66

View Full Technical Details for DY 268

Technical Data
Citations

Biological Activity for DY 268

DY 268 is a potent FXR antagonist (IC₅₀ = 7.5 nM). Exhibits no detectable cytotoxicity in cell-based assays.

Licensing Information

Sold under license from the Beckman Research Institute of the City of Hope.

Technical Data for DY 268

M. Wt	560.66
Formula	C₃₀H₃₂N₄O₅S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1609564-75-1
PubChem ID	90656831
InChi Key	KQSPAAPFKIEUGH-UHFFFAOYSA-N
Smiles	CC1=C(S(N2CCOCC2)(=O)=O)C=C(NC(C3=CN(CC4=CC(OC)=CC=C4)N=C3C5=CC=C(C)C=C5)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DY 268

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	56.07	100

Preparing Stock Solutions for DY 268

The following data is based on the product molecular weight 560.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.78 mL	8.92 mL	17.84 mL
5 mM	0.36 mL	1.78 mL	3.57 mL
10 mM	0.18 mL	0.89 mL	1.78 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for DY 268

References are publications that support the biological activity of the product.

Yu Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg.Med.Chem. 2014 PMID: 24775917