DS2

Tocris Bioscience, part of Bio-Techne | Catalog # 3679

Positive allosteric modulator of GABAA receptors; displays subunit selectivity
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Key Product Details

Description

Positive allosteric modulator of GABAA receptors; displays subunit selectivity

View all GABA-A Receptor Modulators »

Product Description

DS2 is a positive allosteric modulator of GABAA receptors. Potentiates GABA-evoked currents mediated by α4β3δ receptors (EC50 = 142 nM, in vitro). Displays complex selectivity profile, with selectivity for δ-containing receptors (α4/6βxδ > α1βxδ >> γ2 > α4β3 GABAA receptors). Enhances tonic currents of thalamocortical neurons in wild-type mice.

Product Specifications

Molecular Weight

353.83

Formula

C18H12ClN3OS

Storage

Desiccate at +4°C

Purity

≥97% (HPLC)

Chemical Name

4-Chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide

CAS Number

374084-31-8

PubChem ID

979718

InChI Key

AZKMWHRDICVYEI-UHFFFAOYSA-N

SMILES

O=C(C4=CC=C(Cl)C=C4)NC2=C(C3=CC=CS3)N=C1C=CC=CN12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.69 50

Preparing Stock Solutions for DS2

The following data is based on the product molecular weight 353.83

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.65 mL 28.26 mL 56.52 mL
2.5 mM 1.13 mL 5.65 mL 11.30 mL
5 mM 0.57 mL 2.83 mL 5.65 mL
25 mM 0.11 mL 0.57 mL 1.13 mL

Calculators

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Product Documents for DS2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DS2

For research use only

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