DR 4485 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5005
High affinity and selective 5-HT7 antagonist; orally bioavailable
Key Product Details
Description
High affinity and selective 5-HT7 antagonist; orally bioavailable
Product Description
DR 4485 hydrochloride is a high affinity and selective 5-HT7 antagonist (pKi = 8.14). Exhibits selectivity for 5-HT7 over other 5-HT receptors. Inhibits 5-HT-induced cAMP accumulation in HEK-293 cells expressing the 5-HT7 receptor. Orally bioavailable.Product Specifications
Molecular Weight
491.88
Formula
C26H28Cl2N2O.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one hydrochloride
CAS Number
402942-53-4
PubChem ID
90488996
InChI Key
QAERYGXKDZHTFR-UHFFFAOYSA-N
SMILES
ClC1=C2C(C3(CCCCN4CCC(C5=CC=C(Cl)C=C5)=CC4)CCC2)=C(NC3=O)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.19 | 100 |
Preparing Stock Solutions
for DR 4485 hydrochloride
The following data is based on the product molecular weight 491.88
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.03 mL | 10.17 mL | 20.33 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.07 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.03 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Medina Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. J.Med.Chem. 2009 PMID: 19326916
- Kikuchi New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorg.Med.Chem.Lett. 2003 PMID: 12467617
Product Specific Notices for DR 4485 hydrochloride
For research use only
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