DR 2313

Name: DR 2313
Brand: Tocris Bioscience
SKU: 2496

Tocris Bioscience, part of Bio-Techne | Catalog # 2496

COA / SDS

PARP-1 and PARP-2 inhibitor

Discontinued Product

2496 has been discontinued. View all Poly(ADP-ribose) Polymerase Inhibitors products.

Key Product Details

Description:	PARP-1 and PARP-2 inhibitor
Chemical Name:	1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity:	≥99% (HPLC)
Molecular Weight:	182.24

View Full Technical Details for DR 2313

Technical Data
Citations

Biological Activity for DR 2313

DR 2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC₅₀ values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro. Brain penetrant.

Technical Data for DR 2313

M. Wt	182.24
Formula	C₈H₁₀N₂OS
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	284028-90-6
PubChem ID	10219702
InChi Key	HRYKZAKEAVZGJD-UHFFFAOYSA-N
Smiles	CC1=NC(=O)C2=C(N1)CCSC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for DR 2313

References are publications that support the biological activity of the product.

Jagtap and Szabo Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat.Rev.Drug Discov. 2005 PMID: 15864271
Nakajima A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J.Pharmacol.Exp.Ther. 2005 PMID: 15466246

DR 2313

Tocris Bioscience, part of Bio-Techne | Catalog # 2496

Key Product Details

Biological Activity for DR 2313

Technical Data for DR 2313

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for DR 2313

Product Documents for DR 2313

COA

Certificate of Analysis

SDS

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