DPDPE

Tocris Bioscience, part of Bio-Techne | Catalog # 1431

Citations (64)

COA / SDS

Selective δ agonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective δ agonist

Alternative Names

[D-Pen^2,5]Enkephalin,[D-Pen²,D-Pen⁵]Enkephalin

View all delta Opioid Receptor Agonists »

Product Description

DPDPE is a prototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC₅₀ = 5.2 nM), and is antinociceptive in vivo.

Product Specifications

Molecular Weight

645.79

Formula

C₃₀H₃₉N₅O₇S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

88373-73-3

PubChem ID

14679813

InChI Key

MCMMCRYPQBNCPH-NEUULRRLSA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]1C(=O)NCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@H](C(O)=O)C(C)(C)SSC1(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Clark [D-Pen²,D-Pen⁵]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ₁ opiate binding sites. Eur.J.Pharmacol. 1986 PMID: 3025000
Fraser Supraspinal antinociceptive response to [D-Pen^2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other δ-agonists in the rat. J.Pharmacol.Exp.Ther. 2000 PMID: 11082450
Chandrakumar Analogs of the δ opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly³-Phe⁴ amide bond isostere substitutions. J.Med.Chem. 1992 PMID: 1323677