Doxycycline hyclate

Name: Doxycycline hyclate
Brand: Tocris Bioscience
SKU: 4090
Rating: 4 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4090

Citations (2)

(1)

COA / SDS

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Key Product Details

Description:	Broad-spectrum MMP inhibitor; tetracycline derivative
Chemical Name:	(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate
Molecular Weight:	512.94

View Full Technical Details for Doxycycline hyclate

Biological Activity for Doxycycline hyclate

Doxycycline hyclate is a broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Doxycycline hyclate increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems.

For more information about how Doxycycline hyclate may be used, see our protocols: Transdifferentiating Fibroblasts into Neurons, Reprogramming MEFs into Skeletal Muscle Progenitors.

Technical Data for Doxycycline hyclate

M. Wt	512.94
Formula	C₂₂H₂₄N₂O₈.HCl.0.5C₂H₆O.0.5H₂O
Storage	Store at +4°C
CAS Number	24390-14-5
PubChem ID	54686183
InChi Key	UHHHTIKWXBRCLT-VDBOFHIQSA-N
Smiles	OC1=C(C(C2=C(O)[C@@](C(C(C(N)=O)=C(O)[C@H]4N(C)C)=O)(O)[C@@]4([H])[C@@H](O)[C@@]([H])2[C@H]3C)=O)C3=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Doxycycline hyclate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	48.09	100
	DMSO	48.09	100

Preparing Stock Solutions for Doxycycline hyclate

The following data is based on the product molecular weight 512.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.75 mL	19.50 mL
5 mM	0.39 mL	1.95 mL	3.90 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for Doxycycline hyclate

References are publications that support the biological activity of the product.

Wernig A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat.Biotechnol. 2008 PMID: 18594521
Burggraf Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol.Dis. 2007 PMID: 17166729
Franco Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices. Am.J.Pathol. 2006 PMID: 16651635

Citations for Doxycycline hyclate (2)

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Citations are publications that use Bio-Techne products. Selected citations for Doxycycline hyclate include:

Sato et al. (2019) Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells. Stem Cell Reports. 13:352
PMID: 31353225
Kalous et al. (2012) Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. J Neurochem. 122:523
PMID: 22621370

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Customer Reviews for Doxycycline hyclate (1)

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Doxycycline was used to study its resistance pattern against Pseudomonas aeruginosa

Name: Anonymous

Species: Human

Doxycycline was used to study its resistance pattern against Pseudomonas aeruginosa. E coli was used as a standard to compare.

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Product Documents for Doxycycline hyclate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Doxycycline hyclate (internal use), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov