Dopamine hydrochloride

Name: Dopamine hydrochloride
Brand: Tocris Bioscience
SKU: 3548

Catalog # 3548 | Tocris Bioscience a Bio-Techne Brand

Citations (21)

COA / SDS

Endogenous agonist at dopamine D1-5 receptors

Key Product Details

Description:	Endogenous agonist at dopamine D_1-5 receptors
Chemical Name:	3,4-Dihydroxyphenethylamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	189.64

View Full Technical Details for Dopamine hydrochloride

Technical Data
Citations (21) / Reviews

Biological Activity for Dopamine hydrochloride

Dopamine hydrochloride is an endogenous neurotransmitter that acts as an agonist at dopamine D_1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis.

Technical Data for Dopamine hydrochloride

M. Wt	189.64
Formula	C₈H₁₁NO₂.HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	62-31-7
PubChem ID	65340
InChi Key	CTENFNNZBMHDDG-UHFFFAOYSA-N
Smiles	NCCC1=CC(O)=C(O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dopamine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	18.96	100
	DMSO	18.96	100

Preparing Stock Solutions for Dopamine hydrochloride

The following data is based on the product molecular weight 189.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.27 mL	26.37 mL	52.73 mL
5 mM	1.05 mL	5.27 mL	10.55 mL
10 mM	0.53 mL	2.64 mL	5.27 mL
50 mM	0.11 mL	0.53 mL	1.05 mL

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Reconstitution Calculator

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References for Dopamine hydrochloride

References are publications that support the biological activity of the product.

Cools Role of DA in the motivational and cognitive control of behavior. Neuroscientist 2008 PMID: 18660464
Fitzgerald and Dinan Prolactin and DA: what is the connection? A review article. J.Psychopharmacol.
Rivonello Novel insights into DA receptor pharmacology. Eur.J.Endocrinol. 2007 PMID: 17413183

Citations for Dopamine hydrochloride (21)

Showing 1 - 10 of 21 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Dopamine hydrochloride include:

Ning et al. (2023) Autoregulation of GPCR signalling through the third intracellular loop. Nature. 615:734-741
PMID: 36890236
Bryan L et al. (2022) Agonist and antagonist TRUPATH assays for G protein-coupled receptors. STAR Protoc. 3:101259
PMID: 35403009
Mark L et al. (2022) History-dependent dopamine release increases cAMP levels in most basal amygdala glutamatergic neurons to control learning. Cell Rep. 38:110297
PMID: 35081349
Kira E et al. (2022) Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors. Cell Rep. 40:111426
PMID: 36170823
Mou et al. (2021) Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird. Nat Commun. 12:2617
PMID: 33976169
Stefan et al. (2021) New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling. Sci Rep. 11:8288
PMID: 33859231
Sara R et al. (2021) Bingeing on High-Fat Food Enhances Evoked Dopamine Release and Reduces Dopamine Uptake in the Nucleus Accumbens. Obesity (Silver Spring). 29:721-730
PMID: 33660412
Spencer T et al. (2020) Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray. Elife. 9
PMID: 32207681
Fang et al. (2020) Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism. Oncotarget. 11:4224-4242
PMID: 33245718
Mark D et al. (2020) Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons. Neuron. 106:277-290.e6
PMID: 32075716
Thomas C et al. (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell. 179:498-513.e22
PMID: 31585084
Guo (2017) DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.. 16(6):1323
PMID: 28975698
Brzosko et al. (2015) Retroactive modulation of spike timing-dependent plasticity by DA. Elife. 4
PMID: 26516682
Tozzi et al. (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci. 9:192
PMID: 26074768
Gerhold et al. (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 35:9580
PMID: 26134641
Bénédicte et al. (2015) Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metab. 22:646-57
PMID: 26278050
Zheng et al. (2014) Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. Physiol Res. 306:R138
PMID: 24305061
Zhang et al. (2013) Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians. Physiol Behav. 112-113:8
PMID: 23415661
Kucka et al. (2012) Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs. World J Gastroenterol. 61:267
PMID: 22480423
Martin et al. (2012) Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels. Learn Mem. 19:294-9
PMID: 22723051
O'Keeffe et al. (2009) DA-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc Natl Acad Sci U S A. 106:8754
PMID: 19433789

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