DMP 543

Name: DMP 543
Brand: Tocris Bioscience
SKU: 2330

Tocris Bioscience, part of Bio-Techne | Catalog # 2330

Citations (9)

COA / SDS

Potent, orally active ACh release enhancer

Discontinued Product

2330 has been discontinued. View all Two-P Potassium Channels Blockers products.

Key Product Details

Description:	Potent, orally active ACh release enhancer
Chemical Name:	10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
Purity:	≥99% (HPLC)
Molecular Weight:	412.44

View Full Technical Details for DMP 543

Technical Data
Citations

Biological Activity for DMP 543

DMP 543 is an acetylcholine release stimulator. Potently enhances K⁺-stimulated [³H]-ACh release from rat hippocampal slices (EC₅₀ = 700 nM), and increases release of dopamine and glutamate (EC₅₀ values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo. Also K⁺ channel blocker.

Technical Data for DMP 543

M. Wt	412.44
Formula	C₂₆H₁₈F₂N₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	160588-45-4
PubChem ID	9887884
InChi Key	MUJBUUDUXGDXLW-UHFFFAOYSA-N
Smiles	FC1=CC(CC2(CC3=CC(F)=NC=C3)C3=CC=CC=C3C(=O)C3=C2C=CC=C3)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for DMP 543

References are publications that support the biological activity of the product.

Earl 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action. J.Med.Chem. 1998 PMID: 9804701
Zaczek Two new potent neurotransmitter release enhancers, 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-Bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 1998 PMID: 9580619

DMP 543

Tocris Bioscience, part of Bio-Techne | Catalog # 2330

Key Product Details

Biological Activity for DMP 543

Technical Data for DMP 543

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for DMP 543

Product Documents for DMP 543

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected