DMB

Name: DMB
Brand: Tocris Bioscience
SKU: 8874

Tocris Bioscience, part of Bio-Techne | Catalog # 8874

COA / SDS

GSDMD (Gasdermin D) agonist, activator of pyroptosis, also GLP-1R agonist

Key Product Details

Description:	GSDMD (Gasdermin D) agonist, activator of pyroptosis, also GLP-1R agonist
Chemical Name:	6,7-Dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-2-quinoxalinamine
Purity:	≥98% (HPLC)
Molecular Weight:	348.25

View Full Technical Details for DMB

Technical Data
Citations

Biological Activity for DMB

DMB is a Gasdermin D (GSDMD) agonist (EC₅₀ = 0.7 mM). DMB directly bound to GSDMD (K_D = 1.1 mM). DMB activates GSDMD pore formation and pyroptosis without cleaving GSDMD. In vivo, DMB suppresses tumor growth without harming GSDMD-expressing immune cells in mouse tumor models. DMB is also an agonist of glucagon-like peptide 1 receptor. DMB is orally bioavailable.

Technical Data for DMB

M. Wt	348.25
Formula	C₁₃H₁₅Cl₂N₃O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	281209-71-0
PubChem ID	16007289
InChi Key	GNZCSGYHILBXLL-UHFFFAOYSA-N
Smiles	O=S(=O)(C1=NC=2C=C(Cl)C(Cl)=CC2N=C1NC(C)(C)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DMB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.41	50

Preparing Stock Solutions for DMB

The following data is based on the product molecular weight 348.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.74 mL	28.72 mL	57.43 mL
2.5 mM	1.15 mL	5.74 mL	11.49 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
25 mM	0.11 mL	0.57 mL	1.15 mL

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References for DMB

References are publications that support the biological activity of the product.

Fontana Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity. Cell 2024 PMID: 39243763

DMB