(±)-PPCC oxalate
Tocris Bioscience, part of Bio-Techne | Catalog # 3870
Selective sigma (σ) agonist (σ1> σ2)
Key Product Details
Description
Selective sigma (σ) agonist (σ1> σ2)
Product Description
(±)-PPCC oxalate is a selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.Product Specifications
Molecular Weight
469.53
Formula
C24H29NO3.C2H2O4
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
(1R,2S)-rel-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester oxalate
CAS Number
1781628-91-8
PubChem ID
90488889
InChI Key
IGJDSEGFEVKASG-KLELIYFTSA-N
SMILES
CC(C=C3)=CC=C3[C@@]1(C(OC)=O)C[C@@H]1CN2CCC(C4=CC=CC=C4)(O)CC2.CC(C=C7)=CC=C7[C@]5([C@](OC)=O)C[C@H]5CN6CCC(C8=CC=CC=C8)(O)CC6.O=C(O)C(O)=O.O=C(O)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.95 | 100 | |
| Ethanol | 4.7 | 10 |
Preparing Stock Solutions
for (±)-PPCC oxalate
The following data is based on the product molecular weight 469.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.65 mL | 21.30 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Prezzavento A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci. 2008 PMID: 18261749
- Antonini Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J.Neurochem. 2009 PMID: 19245662
- Prezzavento Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem. 2007 PMID: 17328523
Product Specific Notices for (±)-PPCC oxalate
For research use only
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