(±)-Epibatidine

Name: (±)-Epibatidine
Brand: Tocris Bioscience
SKU: 0684
Price: 357 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0684

Citations (3)

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Key Product Details

Description:	High affinity nAChR agonist
Chemical Name:	(±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane
Purity:	≥98% (HPLC)
Molecular Weight:	208.69

View Full Technical Details for (±)-Epibatidine

Biological Activity for (±)-Epibatidine

(±)-Epibatidine is a high affinity nicotinic agonist (K_i values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.

Licensing Information

Sold under license from the NIH, US Patent 5,314,899

Technical Data for (±)-Epibatidine

M. Wt	208.69
Formula	C₁₁H₁₃ClN₂
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	148152-66-3
PubChem ID	1204
InChi Key	NLPRAJRHRHZCQQ-UHFFFAOYSA-N
Smiles	ClC(N=C3)=CC=C3C2C1CCC(C2)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-Epibatidine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	1.23	5
	ethanol	24.55	100

Preparing Stock Solutions for (±)-Epibatidine

The following data is based on the product molecular weight 208.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.79 mL	23.96 mL	47.92 mL
5 mM	0.96 mL	4.79 mL	9.58 mL
10 mM	0.48 mL	2.40 mL	4.79 mL
50 mM	0.10 mL	0.48 mL	0.96 mL

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Reconstitution Calculator

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References for (±)-Epibatidine

References are publications that support the biological activity of the product.

Sharples UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 2000 PMID: 10751429
Marks Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 1998 PMID: 9536034
Gerzarich Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 1995 PMID: 7476906
Badio and Daly Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 1994 PMID: 8183234
Spande Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity. J.Am.Chem.Soc.

Citations for (±)-Epibatidine (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for (±)-Epibatidine include:

Noviello et al. (2021) Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell. 184:2121
PMID: 33735609
Williams et al. (2007) The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens. Br J Pharmacol. 150:906
PMID: 17325648
Beckel et al. (2006) Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells. J Neurosci. 290:F103
PMID: 16144967

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