DL-AP3

Name: DL-AP3
Brand: tocris
SKU: 0125

Catalog # 0125

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	Group I mGlu antagonist; also phosphoserine phosphatase inhibitor
Chemical Name:	DL-2-Amino-3-phosphonopropionic acid
Molecular Weight:	169.07

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Technical Data
Citations (1) / Reviews

Biological Activity

Competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.

Technical Data

M. Wt	169.07
Formula	C₃H₈NO₅P
Storage	Store at RT
CAS Number	5652-28-8
PubChem ID	3857
InChi Key	LBTABPSJONFLPO-UHFFFAOYSA-N
Smiles	NC(CP(O)(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	16.91	100

Preparing Stock Solutions

The following data is based on the product molecular weight 169.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.91 mL	29.57 mL	59.15 mL
5 mM	1.18 mL	5.91 mL	11.83 mL
10 mM	0.59 mL	2.96 mL	5.91 mL
50 mM	0.12 mL	0.59 mL	1.18 mL

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References

References are publications that support the biological activity of the product.

Evans The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 1982 PMID: 7042024
Hawkinson The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur.J.Pharmacol. 1996 PMID: 8832224
Saugstad L-2-Amino-3-phosphonopropionic acid completely antagonizes metabotropic glutamate receptors 1α and 5 in Xenopus oocytes. Eur.J.Pharmacol. 1995 PMID: 7621916

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for DL-AP3 include:

Vance et al. (2015) PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors. J Neurosci. 35:776
PMID: 25589770

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Product Datasheets

COA

Certificate of Analysis

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SDS

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DL-AP3

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Key Product Details

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

SDS

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