(±)-ADX 71743
Tocris Bioscience, part of Bio-Techne | Catalog # 5715
Negative allosteric modulator of mGlu7 receptors; brain penetrant
Key Product Details
Description
Negative allosteric modulator of mGlu7 receptors; brain penetrant
Product Description
(±)-ADX 71743 is a negative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.Product Specifications
Molecular Weight
269.34
Formula
C17H19NO2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone
CAS Number
1431641-29-0
PubChem ID
53391766
InChI Key
CPKZCQHJDFSOJT-UHFFFAOYSA-N
SMILES
CC(C=C1C)=CC=C1C(CC2=C3N=C(CC)O2)CC3=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.93 | 100 | |
| Ethanol | 26.93 | 100 |
Preparing Stock Solutions
for (±)-ADX 71743
The following data is based on the product molecular weight 269.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.71 mL | 18.56 mL | 37.13 mL |
| 5 mM | 0.74 mL | 3.71 mL | 7.43 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.71 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tassin Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network. Front Neural Circuits 2016 PMID: 27199672
- Klar Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J.Neurosci. 2015 PMID: 25972184
Product Specific Notices for (±)-ADX 71743
For research use only
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