(±)-AC 7954 hydrochloride

Name: (±)-AC 7954 hydrochloride
Brand: Tocris Bioscience
SKU: 2484

Tocris Bioscience a Bio-Techne Brand

Catalog # 2484

COA / SDS

Discontinued Product

2484 has been discontinued. View all Urotensin-II Receptor Agonists products.

Key Product Details

Description:	Non-peptide UT receptor agonist
Chemical Name:	(±)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-dihydro-1H-2-benzopyran-1-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	366.28

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Biological Activity for (±)-AC 7954 hydrochloride

(±)-AC 7954 hydrochloride is a highly selective, non-peptide urotensin-II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC₅₀ values are 6.5 and 6.7 respectively).

Technical Data for (±)-AC 7954 hydrochloride

M. Wt	366.28
Formula	C₁₉H₂₀ClNO₂.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	477313-09-0
PubChem ID	9907171
InChi Key	AJPGLOWFIBOGMH-UHFFFAOYSA-N
Smiles	Cl.CN(C)CCC1(CC2=CC=CC=C2C(=O)O1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-AC 7954 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	27.47	75
	DMSO	27.47	75

Preparing Stock Solutions for (±)-AC 7954 hydrochloride

The following data is based on the product molecular weight 366.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.64 mL	18.20 mL	36.40 mL
3.75 mM	0.73 mL	3.64 mL	7.28 mL
7.5 mM	0.36 mL	1.82 mL	3.64 mL
37.5 mM	0.07 mL	0.36 mL	0.73 mL

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References for (±)-AC 7954 hydrochloride

References are publications that support the biological activity of the product.

Lehmann Novel potent and efficacious nonpeptidic urotensin II receptor agonists. J.Med.Chem. 2006 PMID: 16570919
Lavecchia Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists. J.Med.Chem. 2005 PMID: 15801838
Croston Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954). J.Med.Chem. 2002 PMID: 12408704

Citations for (±)-AC 7954 hydrochloride

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