DL 175

Name: DL 175
Brand: Tocris Bioscience
SKU: 7082

Tocris Bioscience, part of Bio-Techne | Catalog # 7082

Citations (29)

COA / SDS

Potent and selective GPR84 agonist

Key Product Details

Description:	Potent and selective GPR84 agonist
Chemical Name:	3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
Purity:	≥98% (HPLC)
Molecular Weight:	299.75

View Full Technical Details for DL 175

Technical Data
Citations

Biological Activity for DL 175

DL 175 is a potent and selective GPR84 biased agonist (EC₅₀ = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.

Compound Libraries for DL 175

DL 175 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DL 175

M. Wt	299.75
Formula	C₁₇H₁₄ClNO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2487253-25-6
InChi Key	FXOVKEUUTXBOJZ-UHFFFAOYSA-N
Smiles	ClC1=C(C=CC=C2)C2=C(OCCC3=C[N+]([O-])=CC=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DL 175

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.98	100
	ethanol	29.98	100

Preparing Stock Solutions for DL 175

The following data is based on the product molecular weight 299.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.34 mL	16.68 mL	33.36 mL
5 mM	0.67 mL	3.34 mL	6.67 mL
10 mM	0.33 mL	1.67 mL	3.34 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for DL 175

References are publications that support the biological activity of the product.

Lucy A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages. ACS Chem.Biol 2019 PMID: 31465201