DIPPA hydrochloride

Name: DIPPA hydrochloride
Brand: Tocris Bioscience
SKU: 0794
Price: 197 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0794

Citations (2)

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Key Product Details

Description:	Selective and irreversible κ antagonist
Chemical Name:	2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	484.87

View Full Technical Details for DIPPA hydrochloride

Biological Activity for DIPPA hydrochloride

DIPPA hydrochloride is an an irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.

Technical Data for DIPPA hydrochloride

M. Wt	484.87
Formula	C₂₂H₂₃Cl₂N₃OS.HCl
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	155512-52-0
PubChem ID	45073425
InChi Key	BNWYENYHNOESCX-ZMBIFBSDSA-N
Smiles	ClC1=C(Cl)C=C(CC(N([C@@](CN3CCCC3)([H])C2=CC=CC(N=C=S)=C2)C)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DIPPA hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	14.55	30
	DMSO	24.24	50

Preparing Stock Solutions for DIPPA hydrochloride

The following data is based on the product molecular weight 484.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.12 mL	20.62 mL	41.25 mL
2.5 mM	0.82 mL	4.12 mL	8.25 mL
5 mM	0.41 mL	2.06 mL	4.12 mL
25 mM	0.08 mL	0.41 mL	0.82 mL

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References for DIPPA hydrochloride

References are publications that support the biological activity of the product.

Chang 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J.Med.Chem. 1994 PMID: 8201586
Chang κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists. J.Med.Chem. 1994 PMID: 7799399

Citations for DIPPA hydrochloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for DIPPA hydrochloride include:

Jones et al. (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol. 80:1478
PMID: 20696141
Carr and Lucki (2010) Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats. Psychopharmacology (Berl). 210:295
PMID: 20369354

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Product Documents for DIPPA hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.