Dinaciclib

Product Description

Dinaciclib is a potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9 activity in vitro (IC₅₀ values are 1, 1, 3 and 4 nM, respectively). The compound inhibits DNA replication by blocking thymidine DNA incorporation in A2780 cells (IC₅₀ = 4 nM). Dinaciclib induces regression of established solid tumors in mouse models and shows antiviral activity against SARS-CoV-2 in vitro (Vero E6, IC₅₀ = 0.127 μM; A549-ACE2, IC₅₀ = 0.032 μM).

Solubility

Preparing Stock Solutions for Dinaciclib

The following data is based on the product molecular weight 396.50

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.50 mL	2.52 mL	5.04 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bouhaddou The global phosphorylation landscape of SARS-CoV-2 infection. Cell 2020 PMID: 32645325
• Parry Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Mol.Cancer Ther. 2010 PMID: 20663931