Diltiazem hydrochloride

Name: Diltiazem hydrochloride
Brand: tocris
SKU: 0685

Catalog # 0685

Citations (5)

Datasheet / COA / SDS

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Key Product Details

Description:	Ca_V1.x blocker
Chemical Name:	(2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	450.98

View Full Technical Details for Diltiazem hydrochloride

Biological Activity

Diltiazem hydrochloride is an antihypertensive and cardioprotective agent; an inhibitor of L-type Ca²⁺ channels.

Compound Libraries

Diltiazem hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	450.98
Formula	C₂₂H₂₆N₂O₄S.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	33286-22-5
PubChem ID	62920
InChi Key	HDRXZJPWHTXQRI-BHDTVMLSSA-N
Smiles	[H][C@]2(C3=CC=C(OC)C=C3)[C@@]([H])(OC(C)=O)C(N(CCN(C)C)C1=CC=CC=C1S2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		100
	DMSO	45.1	100

Preparing Stock Solutions

The following data is based on the product molecular weight 450.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.09 mL	22.17 mL
5 mM	0.44 mL	2.22 mL	4.43 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Dagani Effects of dilt. on bioenergetics, K⁺ gradients, and free cytosolic Ca²⁺ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 1989 PMID: 2795006
Gandia Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by dilt. Br.J.Pharmacol. 1996 PMID: 8818357
Ishibashi Block of P-type Ca²⁺ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera. Brain Res. 1995 PMID: 8574653
Kraus Molecular mechanisms of dilt. interaction with L-type Ca²⁺ channels. J.Biol.Chem. 1998 PMID: 9765241
Merck Index

Citations (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Diltiazem hydrochloride include:

Begam et al. (2018) DTZ improves contractile properties of skeletal muscle in dysferlin-deficient BLAJ mice, but does not reduce contraction-induced muscle damage. Physiol Rep. 6:e13727
PMID: 29890050
Hernández-Cascales (2017) Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium. PeerJ. 5:e3113
PMID: 28382232
Lobeck et al. (2016) Rhesus rotavirus VP6 regulates ERK-dependent calcium influx in cholangiocytes. Virology. 499:185
PMID: 27668997
Cramer et al. (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. PLoS One. 35:5664
PMID: 25855180
Fransen et al. (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Brain Behav. 10:e0121634
PMID: 25803863

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Showing 1 - 5 of 5 citations Showing All

Product Documents

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Diltiazem hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Diltiazem hydrochloride

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Biological Activity

Compound Libraries

Technical Data

Solubility

Preparing Stock Solutions

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Dilution Calculator

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References

Citations (5)

Product Documents

COA

Certificate of Analysis

SDS

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