Dihydrexidine hydrochloride

Name: Dihydrexidine hydrochloride
Brand: Tocris Bioscience
SKU: 0884
Rating: 5 (0 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0884

Citations (4)

(1)

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Key Product Details

Description:	Selective D₁-like agonist
Chemical Name:	(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	303.79

View Full Technical Details for Dihydrexidine hydrochloride

Biological Activity for Dihydrexidine hydrochloride

Dihydrexidine hydrochloride is an a potent, full efficacy dopamine D₁ agonist which shows no agonist activity at peripheral D₂ receptors or adrenoceptors at doses which cause maximal stimulation of D₁ sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.

Licensing Information

Sold under license, US Patent 5,047,536

Technical Data for Dihydrexidine hydrochloride

M. Wt	303.79
Formula	C₁₇H₁₇NO₂.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	137417-08-4
PubChem ID	11403931
InChi Key	IJYUPBNUPIRQEP-SATBOSKTSA-N
Smiles	OC1=C(O)C=C(CC[C@]3([H])[C@@]([H])2C4=C(C=CC=C4)CN3)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dihydrexidine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.04	10
	DMSO	15.19	50

Preparing Stock Solutions for Dihydrexidine hydrochloride

The following data is based on the product molecular weight 303.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.58 mL	32.92 mL	65.83 mL
2.5 mM	1.32 mL	6.58 mL	13.17 mL
5 mM	0.66 mL	3.29 mL	6.58 mL
25 mM	0.13 mL	0.66 mL	1.32 mL

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References for Dihydrexidine hydrochloride

References are publications that support the biological activity of the product.

Kholi Dihydrexidine: a new potent peripheral DA D₁ receptor agonist. Eur.J.Pharmacol. 1993 PMID: 8100195
Taylor Dihydrexidine, a full DA D₁ agonist, reduces MPTP-induced parkinsonism in monkeys. Eur.J.Pharmacol. 1991 PMID: 1680717
Brewster Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective DA D₁ full agonist. J.Med.Chem. 1990 PMID: 1971308
Lovenberg Dihydrexidine, a novel selective high potency, full DA D-1 receptor agonist. Eur.J.Pharmacol. 1989 PMID: 2572425

Citations for Dihydrexidine hydrochloride (4)

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Citations are publications that use Bio-Techne products. Selected citations for Dihydrexidine hydrochloride include:

Parker and Kooi (2014) Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions. J Neurosci. 453:42525
PMID: 24583243
Urizar et al. (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Anal Biochem. 7:624
PMID: 21785426
Smith et al. (2005) DArgic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron. 45:765
PMID: 15748851
Gorelova et al. (2002) Mechanisms of DA activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex. J Neurophysiol. 88:3150
PMID: 12466437

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Customer Reviews for Dihydrexidine hydrochloride (1)

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Dose Response of Tango D1-bla Dopamine Receptor Signaling

Name: Chandra Menendez

Assay Type: In Vitro

Cell Line/Tissue: Tango D1-bla U20S

I used this as our positive control when testing dose responses following treatment with our Tango D1-bla U20S cells to measure dopamine receptor 1 activity following treatment with Dihydrexidine.

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Product Documents for Dihydrexidine hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.