Desipramine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3067
Selective inhibitor of noradrenalin transporters
Key Product Details
Description
Selective inhibitor of noradrenalin transporters
Product Description
Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).Product Specifications
Molecular Weight
302.84
Formula
C18H22N2.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
CAS Number
58-28-6
PubChem ID
65327
InChI Key
XAEWZDYWZHIUCT-UHFFFAOYSA-N
SMILES
CNCCCN2C1=CC=CC=C1CCC3=C2C=CC=C3.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.28 | 100 |
Preparing Stock Solutions
for Desipramine hydrochloride
The following data is based on the product molecular weight 302.84
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.30 mL | 16.51 mL | 33.02 mL |
| 5 mM | 0.66 mL | 3.30 mL | 6.60 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.30 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhao NE transporter regulation mediates the long-term behavioral effects of the antidepressant desipr. Neuropsychopharmacol.
- Torres Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 2003 PMID: 12511858
Product Specific Notices for Desipramine hydrochloride
For research use only
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