Demethylasterriquinone B1

Product Description

Demethylasterriquinone B1 is a selective insulin receptor (IR) activator (EC₅₀ values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.

Solubility

Preparing Stock Solutions for Demethylasterriquinone B1

The following data is based on the product molecular weight 506.59

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.87 mL	19.74 mL
5 mM	0.39 mL	1.97 mL	3.95 mL
10 mM	0.20 mL	0.99 mL	1.97 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wilkie The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors. J.Neurochem. 2001 PMID: 11553687
• Webster Signaling effects of demethylasterriquinone B1, a selective Ins receptor modulator. Chembiochem 2003 PMID: 12740809
• Salituro Discovery of a small molecule Ins receptor activator. Recent Prog.Horm.Res. 2001 PMID: 11237209
• Weber A novel Ins mimetic without a proliferative effect on vascular smooth muscle cells. J.Vasc.Surg. 2000 PMID: 11107083
• Kim Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the Ins mimic demethylasterriquinone B1. J.Med.Chem. 2007 PMID: 17595071