dCeMM2
Tocris Bioscience, part of Bio-Techne | Catalog # 7525
Molecular glue Degrader; induces ubiquitination and degradation of cyclin K
Key Product Details
Description
Molecular glue Degrader; induces ubiquitination and degradation of cyclin K
Product Description
dCeMM2 is a molecular glue degrader. Induces ubiquitination and degradation of cyclin K by eliciting an interaction of CDK12-cyclin K with a CRL4B ligase complex. dCeMM2 displays near-total degradation of protein at 2.5 μM within 2h. Cell-permeable.Product Specifications
Molecular Weight
370.82
Formula
C16H11ClN6OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(5-Chloro-2-pyridinyl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)acetamide
CAS Number
296771-07-8
PubChem ID
5286209
InChI Key
VFWVTIHYVUKNGR-UHFFFAOYSA-N
SMILES
O=C(NC1=NC=C(Cl)C=C1)CSC2=NN=C3C(NC4=C3C=CC=C4)=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.54 | 50 |
Preparing Stock Solutions
for dCeMM2
The following data is based on the product molecular weight 370.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.39 mL | 26.97 mL | 53.93 mL |
| 2.5 mM | 1.08 mL | 5.39 mL | 10.79 mL |
| 5 mM | 0.54 mL | 2.70 mL | 5.39 mL |
| 25 mM | 0.11 mL | 0.54 mL | 1.08 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mayor-Ruiz Rational discovery of molecular glue degraders via scalable chemical profiling. Nat.Chem.Biol. 2020 PMID: 32747809
Product Specific Notices for dCeMM2
For research use only
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