Daunorubicin hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1467
DNA topoisomerase II inhibitor
Key Product Details
Description
DNA topoisomerase II inhibitor
Alternative Names
Daunomycin
Product Description
Daunorubicin hydrochloride is a DNA topoisomerase II inhibitor. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo. Reduces tau mRNA levels in vitro.Anticancer agent. Exhibits activity against nonlymphocytic leukemia. Identified as targeting human host proteins that interact with SARS-CoV-2. Also enhances adeno-associated virus transduction of HeLa cells in vitro.Product Specifications
Molecular Weight
563.99
Formula
C27H29NO10.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
(8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride
CAS Number
23541-50-6
PubChem ID
3085106
InChI Key
GUGHGUXZJWAIAS-CFCXLQPVSA-N
SMILES
NC1CC(O[C@H]2C[C@@]([C@@](C)=O)(O)CC3=C2C(O)=C5C(C(C4=CC=CC(OC)=C4C5=O)=O)=C3O)OC(C)C1O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50 |
Preparing Stock Solutions
for Daunorubicin hydrochloride
The following data is based on the product molecular weight 563.99
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.55 mL | 17.73 mL | 35.46 mL |
| 2.5 mM | 0.71 mL | 3.55 mL | 7.09 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.55 mL |
| 25 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859
- Pommier DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem.Biol. 2010 PMID: 20534341
- Nicolson Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 2016 PMID: 27147738
- Dickey Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol.Neurodegen. 2006 PMID: 16930453
- Laurent and Jaffrezou Signaling pathways activated by daunoru. Blood 2001 PMID: 11493433
- Gewirtz A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunoru. Biochem.Pharmacol. 1999 PMID: 10075079
- Aubel-Sadron and Londos-Gagliardi Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie 1984 PMID: 6380596
Product Specific Notices for Daunorubicin hydrochloride
For research use only
⚠ WARNING: This product can expose you to chemicals including Daunorubicin hydrochloride , which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
Loading...
Loading...
Loading...