Darunavir

Name: Darunavir
Brand: Tocris Bioscience
SKU: 6710
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6710

(1)

COA / SDS

Highly potent HIV protease inhibitor

Key Product Details

Description:	Highly potent HIV protease inhibitor
Chemical Name:	(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	547.66

View Full Technical Details for Darunavir

Technical Data
Citations / Reviews (1)

Biological Activity for Darunavir

Darunavir is a highly potent HIV protease inhibitor (IC₅₀ = 3 - 6 nM, depending on laboratory HIV-1 strain). Displays activity in cells infected with clinical HIV-1 strains shown to have resistance to other protease inhibitors.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Compound Libraries for Darunavir

Darunavir is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Darunavir

M. Wt	547.66
Formula	C₂₇H₃₇N₃O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	206361-99-1
PubChem ID	213039
InChi Key	CJBJHOAVZSMMDJ-HEXNFIEUSA-N
Smiles	[H][C@@]12CCO[C@@]1(OC[C@@H]2OC(N[C@H]([C@@H](CN(S(=O)(C3=CC=C(C=C3)N)=O)CC(C)C)O)CC4=CC=CC=C4)=O)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Darunavir

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.77	100

Preparing Stock Solutions for Darunavir

The following data is based on the product molecular weight 547.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.83 mL	9.13 mL	18.26 mL
5 mM	0.37 mL	1.83 mL	3.65 mL
10 mM	0.18 mL	0.91 mL	1.83 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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Reconstitution Calculator

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References for Darunavir

References are publications that support the biological activity of the product.

Koh Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob.Agents Chemother. 2003 PMID: 14506019
Ghosh Potent HIV protease inhibitors incorporating high-affinity P₂-ligands and (R)-(hydroxyethylamino)sulfonamide isostere. Bioorg.Med.Chem.Lett. 1998 PMID: 9871583