Dantrolene, sodium salt

Name: Dantrolene, sodium salt
Brand: Tocris Bioscience
SKU: 0507
Rating: 4 (1 reviews)

Catalog # 0507

Citations (9)

(1)

COA / SDS

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Key Product Details

Description:	Ca²⁺ release inhibitor
Chemical Name:	1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	336.23

View Full Technical Details for Dantrolene, sodium salt

Biological Activity

Inhibits release of Ca²⁺ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

Technical Data

M. Wt	336.23
Formula	C₁₄H₉N₄NaO₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	14663-23-1
PubChem ID	6604100
InChi Key	KSRLIXGNPXAZHD-HAZZGOGXSA-M
Smiles	O=C([N-]3)N(CC3=O)/N=C/C1=CC=C(C2=CC=C([N+]([O-])=O)C=C2)O1.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.36	10

Preparing Stock Solutions

The following data is based on the product molecular weight 336.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.74 mL	148.71 mL	297.42 mL
0.5 mM	5.95 mL	29.74 mL	59.48 mL
1 mM	2.97 mL	14.87 mL	29.74 mL
5 mM	0.59 mL	2.97 mL	5.95 mL

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References

References are publications that support the biological activity of the product.

Zhao Dantrolene inhibition of ryanodine receptor Ca²⁺ release channels. J.Biol.Chem. 2001 PMID: 11278295
O'Mara Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus. Neuroscience 1995 PMID: 8577362
Hotchkiss and Karl Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. Proc.Natl.Acad.Sci.U.S.A. 1994 PMID: 8159702

Citations for Dantrolene, sodium salt (9)

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Citations are publications that use Bio-Techne products. Selected citations for Dantrolene, sodium salt include:

Battefeld et al. (2019) High-Frequency Microdomain Ca²⁺ Transients and Waves during Early Myelin Internode Remodeling. Cell Rep. 26:182
PMID: 30605675
Florea et al. (2017) Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget. 8:22876
PMID: 28206967
Agarwal et al. (2017) Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 93:587
PMID: 28132831
Efthymiou et al. (2015) Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. Int J Mol Sci. 4:230
PMID: 25637190
Lin et al. (2015) Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. FEMS Immunol Med Microbiol. 16:5555
PMID: 25768340
Wang et al. (2015) Role of Na+/Ca2+ exchanger in Ca2+ homeostasis in rat suprachiasmatic nucleus neurons. J Neurophysiol. 113:2114
PMID: 25568156
Patel et al. (2009) Mobilization of calcium from intracellular stores facilitates somatodendritic DA release. J Neurosci. 29:6568
PMID: 19458227
Drdla and Sandkühler (2008) Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo. Mol Pain. 4:18
PMID: 18507818
Wieland et al. (2006) Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. J Pharmacol Exp Ther. 47:296
PMID: 16831218

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Dantrolene modulates synaptic function

Name: Anonymous

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: Hippocampus

Dantrolene was used to test impact of Ca2+ efflux from internal stores on neurotransmitter vesicle release in living neurons. Dantrolene, being added to intracellular solution, suppressed release of synaptic vesicles. Figure: change of a neuron electrical capacitance in response to series of electrical stimuli. Increase of electrical capacitance reflects increased number of vesicles fusing with cell membrane.

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