Damnacanthal

Name: Damnacanthal
Brand: Tocris Bioscience
SKU: 1936

Tocris Bioscience a Bio-Techne Brand

Catalog # 1936

COA / SDS

Discontinued Product

1936 has been discontinued. View all Src Family Kinase Inhibitors products.

Key Product Details

Description:	Potent, selective p56^lck inhibitor; also LIMK1/2 inhibitor
Chemical Name:	9,10-Dihydroxy-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde
Purity:	≥98% (HPLC)
Molecular Weight:	282.25

View Full Technical Details for Damnacanthal

Biological Activity for Damnacanthal

Damnacanthal is a potent inhibitor of p56^lck tyrosine kinase activity (IC₅₀ = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59^fyn and p60^src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Mobilizes intracellular Ca²⁺ in dermal fibroblasts and inhibits Ras function. Also inhibits LIMK1/2, as well as migration and invasion of breast cancer cells in vitro.

Technical Data for Damnacanthal

M. Wt	282.25
Formula	C₁₆H₁₀O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	477-84-9
PubChem ID	2948
InChi Key	IPDMWUNUULAXLU-UHFFFAOYSA-N
Smiles	O=C2C3=C(C=C(O)C(C=O)=C3OC)C(C1=CC=CC=C12)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Damnacanthal

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.06	25

Preparing Stock Solutions for Damnacanthal

The following data is based on the product molecular weight 282.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	14.17 mL	70.86 mL	141.72 mL
1.25 mM	2.83 mL	14.17 mL	28.34 mL
2.5 mM	1.42 mL	7.09 mL	14.17 mL
12.5 mM	0.28 mL	1.42 mL	2.83 mL

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References for Damnacanthal

References are publications that support the biological activity of the product.

Aoki Mechanism of damnacanthal-induced [Ca²⁺]_i elevation in human dermal fibroblasts. Eur.J.Pharmacol. 2000 PMID: 10650151
Faltynek Damnacanthal is a highly potent, selective inhibitor fo p56lck tyrosine kinase activity. Biochemistry 1995 PMID: 7547985
Hiramatsu Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia. Cancer Lett. 1993 PMID: 7693328

Citations for Damnacanthal

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