[D-Lys³]-GHRP-6

Name: [D-Lys 3 ]-GHRP-6
Brand: Tocris Bioscience
SKU: 1922

Catalog # 1922 | Tocris Bioscience a Bio-Techne Brand

Citations (6)

COA / SDS

Ghrelin receptor antagonist

Key Product Details

Description:	Ghrelin receptor antagonist
Molecular Weight:	930.12

View Full Technical Details for [D-Lys³]-GHRP-6

Technical Data
Citations (6) / Reviews

Biological Activity for [D-Lys³]-GHRP-6

[D-Lys³]-GHRP-6 is an antagonist at the ghrelin receptor (GHS-R1a) (IC₅₀ = 0.9 μM). Also weakly binds to melanocortin receptors (K_i = 26-120 μM). Centrally active in vivo.

Technical Data for [D-Lys³]-GHRP-6

M. Wt	930.12
Formula	C₄₉H₆₃N₁₃O₆
Single Letter Sequence	HWKWFK (Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	136054-22-3
PubChem ID	5311279
InChi Key	MGSNWNLPMHXGDD-DFWOJPNQSA-N
Smiles	[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for [D-Lys³]-GHRP-6

Solubility

Soluble to 0.5mg/ml in water

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References for [D-Lys³]-GHRP-6

References are publications that support the biological activity of the product.

Pinilla Role of ghrelin in the control of GH secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology 2003 PMID: 12624529
Traebert Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J.Neuroendocrinol. 2002 PMID: 12121496
Schioth Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 1997 PMID: 9574823

Citations for [D-Lys³]-GHRP-6 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for [D-Lys³]-GHRP-6 include:

Murtuza and Isokawa (2018) Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus. J Neurochem. 144:58
PMID: 29063591
Hashiguchi (2017) Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS One. 12(9):e0184261
PMID: 28877214
Kamei et al. (2017) Rikkunshito prevents PacT.-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice. PLoS One. 12:e0171819
PMID: 28182729
Gomez and (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res. 38:2436
PMID: 25257292
Song et al. (2013) Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion. PLoS One. 8:e65422
PMID: 23762368
Kemp et al. (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. PLoS Comput Biol. 57:633
PMID: 21220707

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Showing 1 - 6 of 6 citations Showing All

Product Documents for [D-Lys³]-GHRP-6

COA

Certificate of Analysis

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[D-Lys³]-GHRP-6

Catalog # 1922 | Tocris Bioscience a Bio-Techne Brand

Key Product Details

Biological Activity for [D-Lys³]-GHRP-6

Technical Data for [D-Lys³]-GHRP-6

Solubility for [D-Lys³]-GHRP-6

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [D-Lys³]-GHRP-6

Citations for [D-Lys³]-GHRP-6 (6)

Product Documents for [D-Lys³]-GHRP-6

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Certificate of Analysis

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[D-Lys3]-GHRP-6

Catalog # 1922 | Tocris Bioscience a Bio-Techne Brand

Key Product Details

Biological Activity for [D-Lys3]-GHRP-6

Technical Data for [D-Lys3]-GHRP-6

Solubility for [D-Lys3]-GHRP-6

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [D-Lys3]-GHRP-6

Citations for [D-Lys3]-GHRP-6 (6)

Product Documents for [D-Lys3]-GHRP-6

COA

Certificate of Analysis

SDS

Bio-Techne Brands

[D-Lys³]-GHRP-6

Biological Activity for [D-Lys³]-GHRP-6

Technical Data for [D-Lys³]-GHRP-6

Solubility for [D-Lys³]-GHRP-6

References for [D-Lys³]-GHRP-6

Citations for [D-Lys³]-GHRP-6 (6)

Product Documents for [D-Lys³]-GHRP-6