[D-Lys³]-GHRP-6

Name: [D-Lys 3 ]-GHRP-6
Brand: Tocris Bioscience
SKU: 1922

Tocris Bioscience, part of Bio-Techne | Catalog # 1922

Citations (35)

COA / SDS

Ghrelin receptor antagonist

Key Product Details

Description:	Ghrelin receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	930.12

View Full Technical Details for [D-Lys³]-GHRP-6

Technical Data
Citations

Biological Activity for [D-Lys³]-GHRP-6

[D-Lys³]-GHRP-6 is an antagonist at the ghrelin receptor (GHS-R1a) (IC₅₀ = 0.9 μM). Also weakly binds to melanocortin receptors (K_i = 26-120 μM). Centrally active in vivo.

Technical Data for [D-Lys³]-GHRP-6

M. Wt	930.12
Formula	C₄₉H₆₃N₁₃O₆
Single Letter Sequence	HWKWFK (Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	136054-22-3
PubChem ID	5311279
InChi Key	MGSNWNLPMHXGDD-DFWOJPNQSA-N
Smiles	[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for [D-Lys³]-GHRP-6

Solubility

Soluble to 0.5mg/ml in water

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References for [D-Lys³]-GHRP-6

References are publications that support the biological activity of the product.

Schioth Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 1997 PMID: 9574823
Traebert Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J.Neuroendocrinol. 2002 PMID: 12121496
Pinilla Role of ghrelin in the control of GH secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology 2003 PMID: 12624529

[D-Lys³]-GHRP-6

Tocris Bioscience, part of Bio-Techne | Catalog # 1922

Key Product Details

Biological Activity for [D-Lys³]-GHRP-6

Technical Data for [D-Lys³]-GHRP-6

Solubility for [D-Lys³]-GHRP-6

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [D-Lys³]-GHRP-6

Product Documents for [D-Lys³]-GHRP-6

COA

Certificate of Analysis

SDS

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[D-Lys3]-GHRP-6

Tocris Bioscience, part of Bio-Techne | Catalog # 1922

Key Product Details

Biological Activity for [D-Lys3]-GHRP-6

Technical Data for [D-Lys3]-GHRP-6

Solubility for [D-Lys3]-GHRP-6

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [D-Lys3]-GHRP-6

Product Documents for [D-Lys3]-GHRP-6

COA

Certificate of Analysis

SDS

[D-Lys³]-GHRP-6

Biological Activity for [D-Lys³]-GHRP-6

Technical Data for [D-Lys³]-GHRP-6

Solubility for [D-Lys³]-GHRP-6

References for [D-Lys³]-GHRP-6

Product Documents for [D-Lys³]-GHRP-6