D-CPP-ene
Tocris Bioscience, part of Bio-Techne | Catalog # 1265
Potent competitive NMDA antagonist
Key Product Details
Description
Potent competitive NMDA antagonist
Alternative Names
Midafotel,SDZ EAA 494
Product Description
D-CPP-ene is a potent and competitive NMDA antagonist (Ki = 40 nM). Centrally active following systemic administration.Product Specifications
Molecular Weight
250.19
Formula
C8H15N2O5P
Storage
Desiccate at RT
Chemical Name
D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid
CAS Number
117414-74-1
PubChem ID
6435801
InChI Key
VZXMZMJSGLFKQI-ABVWVHJUSA-N
SMILES
O=P(/C=C/CN1C[C@H]([C@](O)=O)NCC1)(O)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25 | 100 |
Preparing Stock Solutions
for D-CPP-ene
The following data is based on the product molecular weight 250.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.00 mL | 19.98 mL | 39.97 mL |
| 5 mM | 0.80 mL | 4.00 mL | 7.99 mL |
| 10 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Potschka Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of DA and DA and serotonin metabolites in striatum of kindled and non-kindled rats. Eur.J.Pharmacol. 1999 PMID: 10422758
- Aebischer Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene). Helv.Chim.Acta
- Lowe D-CPP-ene (SDZ EAA 494), a potent and competitive N-MthD.-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci.Lett. 1990 PMID: 2166255
Product Specific Notices for D-CPP-ene
For research use only
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